high purity Ergothioneine cas 497-30-3 cosmetic raw material 60%~99%

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$500.00 - $1,500.00 / Gram | 1 Gram/Grams (Min. Order)
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Overview
Quick Details
CAS No.:
497-30-3
Other Names:
Ergothioneine
MF:
C9H15N3O2S
EINECS No.:
497-30-3
Type:
Pharmaceutical Intermediates
Purity:
99%
Brand Name:
HHD
Model Number:
497-30-3
Application:
COSMETIC RAW MATERIAL
Appearance:
white powder
colour:
white powder
Product Name:
Ergothioneine
Latin Name:
Ergothioneine
Shelf Life:
2 Years Proper Storage
Keyword:
Ergothioneine
Storage:
Cool Dry Place
MOQ:
1gram
CAS No:
497-30-3
Form:
powder Ergothioneine
Specification:
60%-99%
Supply Ability
Supply Ability:
1 Kilogram/Kilograms per Month
Packaging & Delivery
Packaging Details
1g;10g;100g;500g;1kg
Port
SH

 
C9H15N3O2S
Molar mass229.30 g/mol
Appearancewhite solid
Melting point275 to 277 °C (527 to 531 °F; 548 to 550 K)

 

 

 

 

Abstract

Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other animals through a transporter, OCTN1, and accumulates to high levels in certain tissues. Ergothioneine is not rapidly metabolised, or excreted in urine and is present in many, if not all, human tissues and body fluids. Ergothioneine has powerful antioxidant and cytoprotective properties in vitro and there is evidence that the body may concentrate it at sites of tissue injury by raising OCTN1 levels. Decreased blood and/or plasma levels of ergothioneine have been observed in some diseases, suggesting that a deficiency could be relevant to the disease onset or progression. This brief Review explores the possible roles of ergothioneine in human health and disease.

Metabolism and sources

Ergothioneine has been found in bacteria, plants and animals, sometimes at millimolar levels. Foods found to contain ergothioneine include liverkidneyblack beanskidney bean and oat bran, with the highest levels in bolete and oyster mushrooms.Levels can be variable, even within species and some tissues can contain much more than others. In the human body, the largest amounts of ergothioneine are found in erythrocyteseye lens and semen,[3] and it is also present in the skin.

Although many species contain ergothioneine, only a few make it, the others absorbing it from their diet or, in the case of plants, from their environment. Biosynthesis has been detected in Actinobacteria, such as Mycobacterium smegmatis and certain fungi, such as Neurospora crassa.

The metabolic pathway to produce ergothioneine starts with the methylation of histidine to produce histidine betaine (hercynine). The sulfur atom is then incorporated from cysteine.[10][13] The biosynthetic genes of ergothioneine have been described in Mycobacterium smegmatis,Neurospora crassa, and Schizosaccharomyces pombe.

Other species of bacteria, such as Bacillus subtilisEscherichia coliProteus vulgaris and Streptococcus, as well as fungi in the Saccharomycotina cannot make ergothioneine

  

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