research chemical trans-ISRIB(trans isomer) cas1597403-47-8

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$180.00 - $250.00 / Gram | 1 Gram/Grams (Min. Order)
Lead Time:
Quantity(Grams) 1 - 1 >1
Est. Time(days) 7 Negotiable
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Overview
Quick Details
CAS No.:
1597403-47-8
Other Names:
ISRIB
MF:
C22H24Cl2N2O4
EINECS No.:
MW 451.34 g/mol
Place of Origin:
China
Type:
Pharmaceutical Intermediates
Purity:
98%
Brand Name:
HHD
Model Number:
HHd
Application:
reseach chemcial
Appearance:
powder
Product name:
trans-ISRIB(trans isomer)
Supply Ability
Supply Ability:
1 Kilogram/Kilograms per Month
Packaging & Delivery
Packaging Details
as request
Port
SH
Picture Example:
package-img
Lead Time :
Quantity(Grams) 1 - 1 >1
Est. Time(days) 7 To be negotiated
Basic information
Product name
ISRIB (trans-isoMer)
CAS
1597403-47-8
MF
C22H24Cl2N2O4
Purity
98%
Appearance
white powders
Others
test by HPLC
Product Detail

Description

ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)α phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction.
ISRIB is a blood- brain barrier penetrant, potent and selective inhibitor of integrated stress response (ISR) that impairs adaptation to ER stress. ISRIB is a potent inhibitor of PERK signaling, which potently reverses the effects of eIF2a phosphorylation and restores the cells translation capacity. ISRIB enhances cognitive memory in rodents.


Usage

ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response.

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