Pharmaceutical Intermediates, Syntheses Material Intermediates
Treat Alzheimer's disease
1 Kilogram/Kilograms per Week
Packaging & Delivery
nootropics manufacturer high quality GTS-21/DMXB-A/CAS 148372-04-7
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition of Osprey Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a statistically significant improvement in attention related and memory related tasks.
GTS-21 was O-demethylated to yield compounds that were then subject to glucuronidation. Three of the metabolites in rat urine were isolated and characterized as 4-OH-GTS-21, 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. The major urinary metabolites were 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. In vitro chemical inhibition of cytochrome P450 in human liver microsomes indicated that CYPIA2 and CYP2E1 were the isoforms primarily responsible for the O-demethylation of GTS-21, with some contribution from CYP3A.
Packaging & Shipping
1)Delivery time:within 3 days after got the order
Package Details:aluminum foil bag/dram/on request
1.A novel R&D center with advanced ventilation equipments and modern experiment equipments.
2.Two Large production factories with high capacity and meet the requirements of GMP.
3.Supplying the products from our manufacturers;
4.Custom synthesis of new products;
5.Help sourcing products and suppliers in China;
6.Assist the export and related affairs.
7.Stable quality,professional production & technology;
8.The most competitive price;
9.Steady supply, rapid delivery;
10.Perfect service, honest cooperation.
Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry.
HengHeDa Pharm has a novel R&D center with advancedventilationequipments and modernexperimentequipments; we offer friendly working environment, have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of this makes us provide good quality products with high rating.
HengHeDa Pharm follows the principle of “quality first, customer above and credit fundamentality”, wishing to offer the best products to our customers.