hhdpharm supply bulk powders Unifiram (DM-232) 99% 272786-64-8

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Place of Origin:
Hubei, China
Auxiliaries and Other Medicinal Chemicals, Central Nervous System Agents, Gastrointestinal Agents, Immune Function Agents, Respiratory System Agents, Urinary System Agents, Vitamins, Amino Acids and Coenzymes
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Food Grade, Medicine Grade, Tech Grade
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white powders
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large in stock
pharmaceutical intermediates
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Dry Cool Place
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100 Kilogram/Kilograms per Quarter nootropics sunifiram/noopept Racetams /Coluracetam//oxiracetam
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nootropics sunifiram/noopept Racetams /Coluracetam//oxiracetam cholines Alpha-GPC  




Other Names

(8aR)-2-[(4-fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one, (CAS Number) 272786-64-8, (PubChem) CID 9861054, (ChemSpider) 8036753, (ChEMBL) CHEMBL140717, C13H15FN2O3S, DM232


Unifiram’s Background
Unifiram (DM-232) is another recent entrant in the Racetam family (think piracetam) which is structurally similar to an ampakine and is closely related to Sunifiram (DM-235), with the first studies on the drug being published in 2003.  More studies need to be conducted to fully elucidate the effects of Unifiram, but it appears to be effective as a Nootropic and as an anti-amnesic.


Unifiram Mechanism of Action
Based on the studies conducted, both in vivo and in vitro, Unifiram reverses the effects of AMPA antagonists, NMDA antagonists, and muscarinic antagonists, which would imply the underlying mechanisms of action.  One study found that Unifiram reversed the effects of both AMPA antagonists and NMDA antagonists, both of which mimic glutamate, and are directly correlated to learning and memory.

Two studies noted that Unifiram increased the release of acetylcholine in rats, and a third study showed Unifiram negated the effects of scopolamine; at first glance, these two facts may not seem to be related, but it turns out scopolamine is a muscarinic antagonist specifically affecting the M1 receptor.   Reducing the effect of a muscarinic antagonist could be the explanation for the noted increase in acetylcholine release, as the M1 muscarinic receptor is a cholinergic receptor.  The effect causing Unifiram to inhibit the negative effects of muscarinic antagonism is most likely the same cause for the increase in acetylcholine.


Unifiram Benefits
In the studies conducted, Unifiram was noted to have three primary benefits: anti-amnesia, acetylcholine agonism, and anti-sedative and anti-hypnotic effects.  Two of the studies on Unifiram and its analogs focused on its ability to reverse the amnesic effects of AMPA antagonists and its precognitive effects utilizing the Mouse Passive Avoidance test for their experimental methodology.  Another study noted that Unifiram appears to increase acetylcholine release in rats; acetylcholine is very strongly correlated to memory and learning.  There was one other study done that found, on top of being an anti-amnesic, Unifiram reduces the effects of barbiturates especially the effects of hypnosis and sedation.


Unifiram Dosing
In the few studies done, the most common dose was .1mg/kg in both mice and rats and was found to be anti-amnesic in the water maze test; this dose works out to roughly 2mg in an adult human (70kgs).  One study also used 1mg/kg in rats and found it to have anti-amnesic effects in rats; this dose would be ~17mg for a healthy adult human (70kgs).

Unifiram Toxicity
At the dose of 1mg/kg, the highest dose tested so far, it was found that Unifiram showed no toxicity and had no negative effects on motor coordination.  This would suggest that a dose of .29mg/kg in an adult human should have no negative effects, and should be non-toxic.






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Company Information

Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry.

HengHeDa Pharm has a novel R&D center with advanced ventilation equipments and modern experiment equipments; we offer friendly working environment, have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of this makes us provide good quality products with high rating.

HengHeDa Pharm follows the principle of “quality first, customer above and credit fundamentality”, wishing to offer the best products to our customers.


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Wuhan Hengheda Pharm Co., Ltd
Skype: nancy_nan4
Tel: 86-27-84888681  Fax: 86-27-84888682
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