nootropic sunifiram (DM-235) for attention disorder disease CAS 314728-85-3 free sample for test quality

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Place of Origin:
Hubei, China
Central Nervous System Agents, Vitamins, Amino Acids and Coenzymes
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Food Grade, Medicine Grade
Animal Pharmaceuticals
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99% min
White to light yellow
cystal white powder
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Sunifiram  (DM-235)

Cas 314728-85-3

Synonym 1-benzoyl-4-propanoylpiperazine

Formula: C14H18N2O2

Molecular Weight  246.304

Melting point 94.5°C-95.5°C

Appearance Off-white to white crystalline powder 

Asssy 99%+



 Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric 

 modulator of AMPA receptors, and has nootropic effects in animal studies with significantly

 higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232)


This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.



1.Sunifiram activates AMPA-mediated neurotransmission. 

2.Enhancing LTP in a bell-shaped dose–response relationship.  

3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.



Recommended Dosage: 5-15mg
Directions: Sunifiram is water soluble. Do not use if you are pregnant/breastfeeding.


Sunifiram, also known as DM-235, is a piperazine derivative of Piracetam that is commonly associated with Racetam compounds even though they are technically not part of that particular class.  It has been shown to have nootropic effects in animal test subjects; according to scientific studies, these effects are noted to be stronger than Piracetam.  Currently, it is set aside for research study only.


Medical Interest in Sunifiram

Because scientific study has determined that Sunifiram’s operational mechanics promote properties that are anti-amnesiac in nature, there is great hope that it can potentially be used as a cognitive enhancer.  This level of enhancement is believed to be associated with brain functionality as it relates to learning and memory.  These particular enhancements have been linked to Sunifiram’s ability to improve long-term potentation through the activation of NMDA and AMPA receptors.


Potential Benefits of Sunifiram

According to clinical research on animal test subjects, it has been determined that Sunifiram has a host of potential benefits.  Some of these potential benefits include:

  • Improved decision making
  • A greater ability to convert short-term memory into long-term memory
  • Improved motor skills via increased control over muscle contraction
  • Enhanced memory and retention of learned information and activities

Safety, Tolerance, and Potential Side Effects Regarding Sunifiram

Currently, there is not any known toxicity that is associated with Sunifiram.  Scientific study on animal test subjects which noted Sunifiram’s efficacy (that is, the ability to produce a therapeutic effect of a given intervention) failed to detect any overtly toxic symptoms even when a 1mg dosage was injected.  This dose was significantly higher than Sunifiram’s minimum effective dose of .001 mg.


Scientific research has also determined that animal test subjects have a tendency to build up a tolerance to Sunifiram on a rapid basis.  This process of tolerance is slowed down when Sunifiram was introduced sparingly as opposed to a consistent basis.


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Company Information

Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry.

HengHeDa Pharm has a novel R&D center with advanced ventilation equipments and modern experiment equipments; we offer friendly working environment, have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of this makes us provide good quality products with high rating.

HengHeDa Pharm follows the principle of “quality first, customer above and credit fundamentality”, wishing to offer the best products to our customers.


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Nancy Chuang (Market Director)

Wuhan Hengheda Pharm Co., Ltd
Skype: nancy_nan4
Tel: 86-27-84888681  Fax: 86-27-84888682
Phone:86-013419582772(what's app & wechat)





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