nootropic// NSI 189 cas 1270138-40-3 cheap price with good quality

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Overview
Quick Details
CAS No.:
1270138-40-3
Other Names:
NSI-189
MF:
C22H30N4O
EINECS No.:
NSI-189
Place of Origin:
Hubei, China
Type:
Anesthetic Agents, Antibiotic and Antimicrobial Agents, Antineoplastic Agents, Antiparasitic Agents, Antipyretic Analgesics and NSAIDs, Central Nervous System Agents, Immune Function Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard:
Food Grade, Medicine Grade
Brand Name:
hhd
Model Number:
hhd
Purity:
99% min
Appearance:
White to light yellow powder
SKYPE:
nancy_nan4
Supply Ability
Supply Ability:
10 Kilogram/Kilograms per Month
Packaging & Delivery
Packaging Details
5g/bag ,10g/bag ,500g/bag, 1kg/tin,25kg/drum
Port
any port

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NSI-189

free base cas 1270138-40-3

salt  cas 1270138-41-4 

NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine created by Neuralstem, Inc. Research into NSI-189 has been heavily funded by the Defense Advanced Research Projects Agency (DARPA) and theNational Institutes of Health (NIH).
Molecular Formula: C22H30N4O 
Structural Formula: HOOC (CH2) 7COOH

Molecular weight 366.4998 g/mol

Abstract

the Food and Drug Administration (FDA) have approved the advance to Phase 1b in the ongoing clinical trial to test its neuroregenerative compound, NSI-189.


NSA-189 is a proprietary new chemical entity that stimulates new neuron growth in the hippocampus, an area of the brain believed to be contributory in MDD and other conditions, such as Alzheimer’s disease and Post-traumatic stress disorder (PTSD).  Phase 1b of the clinical trial is to test the safety and tolerability of the drug in depressed patients.
Karl Johe, PhD, Chief Scientific Officer and Chairman of Neuralstem’s Board of Directors, said, “We are pleased to be approved to begin testing NSI-189 in patients who suffer from depression.  Loss of hippocampal volume is a known characteristic in depressed patients.  NSI-189 stimulates neurogenesis and increases hippocampal volume in healthy adult mice, at the same time reversing behavioural symptoms in mouse depression models, so it could address depression at the source.”

 


Maurizio Fava, MD, Slater Family Professor of Psychiatry at Harvard Medical School and Executive Vice Chair of the Department of Psychiatry at Massachusetts General Hospital, is a leading researcher into MDD and helped to design the Neuralstem trial, added, “It is exciting to see a new class of drugs that potentially offers a novel and different approach to this disease moving into patients.”

 


Neuralstem’s technology enabled the creation of neural stem cell lines from areas of the human CNS, including the hippocampus, a part of the brain involved in memory and the generation of new neurons.  From this, Neuralstem has created virtually unlimited amounts of mature human neurons and glia in laboratory dishes which can be used to mimic the natural brain environment to test the drug’s effects.

 


NSI-189 is the lead compound in Neuralstem’s neuroregenerative small molecule drug platform, which the company plans to develop into orally administered drugs for MDD and other psychiatric disorders, such as anxiety, bipolar disorder, PTSD and Alzheimer’s disease.  In previous tests, NSI-189 significantly improved behavioural responses associated with depression.  In humans, it may reverse the human hippocampal atrophy seen in MDD and other disorders, reversing their symptoms.

 

 

 

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Company Information

Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry.

HengHeDa Pharm has a novel R&D center with advanced ventilation equipments and modern experiment equipments; we offer friendly working environment, have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of this makes us provide good quality products with high rating.

HengHeDa Pharm follows the principle of “quality first, customer above and credit fundamentality”, wishing to offer the best products to our customers.

 

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Nancy Chuang (Market Director)

Wuhan Hengheda Pharm Co., Ltd
Skype: nancy_nan4
Tel: 86-27-84888681  Fax: 86-27-84888682
Phone:86-013419582772(what's app & wechat)