Wuhan HHD Supply L-655,708 FG-8094 CAS:130477-52-0 Selective for Alpha5-Containing GABAA Receptors

FOB Reference Price:Get Latest Price
  • 10 - 19 Milligrams
    $20.00
  • >=20 Milligrams
    $15.00
Lead Time:
Quantity(Milligrams) 1 - 10 >10
Est. Time(days) 7 Negotiable
Customization:
Customized logo (Min. Order: 1000 Milligrams)
Customized packaging (Min. Order: 1000 Milligrams)

More

Graphic customization (Min. Order: 1000 Milligrams) Less
Samples:
$20.00 /Milligram | 1 Milligram (Min. Order) | Buy Samples
Report Suspicious Activity
Overview
Quick Details
CAS No.:
130477-52-0
Other Names:
FG-8094
MF:
C18H19N3O4
EINECS No.:
n/a
Place of Origin:
China
Type:
Respiratory System Agents
Grade Standard:
Medicine Grade, Tech Grade
Brand Name:
HHD-Pharm
Purity:
97%,98%,99%%
Product Name:
L-655,708
other name:
L-655708
Appearance:
white powders
Melting point:
175-176 °C
storage:
Room Temperature
Solubility:
DMSO: 6 mg/mL
Supply Ability
Supply Ability:
100 Box/Boxes per Quarter
Packaging & Delivery
Packaging Details
on request
Port
Main port in China
Picture Example:
package-img
Lead Time :
Quantity(Milligrams) 1 - 10 >10
Est. Time(days) 7 To be negotiated
Basic information
Product name
L-655,708
CAS
130477-52-0
MF
C18H19N3O4
Purity
min 97%
Appearance
powders
Others
FG-8094
Product Detail

Description

The in vitro and in vivo properties of L-655,708, a compound with higher affinity for GABA(A) receptors containing an alpha5 compared to an alpha1, alpha2 or alpha3 subunit have been examined further. This compound has weak partial inverse agonist efficacy at each of the four subtypes but, and consistent with the binding data, has higher functional affinity for the alpha5 subtype. In a mouse hippocampal slice model, L-655,708 was able to enhance the long-term potentiation produced by a theta burst stimulation, consistent with a potential role for the alpha5 subtype in processes involving synaptic plasticity, such as learning and memory. When administered in a formulation specifically designed to achieve relatively constant plasma drug concentrations, and therefore maintain selective occupancy of alpha5- compared to alpha1-, alpha2- and alpha3-containing receptors (75+/-4% versus 22+/-10%, respectively), L-655,708 did not alter the dose of pentylenetetrazole required to induce seizures, indicating that the inverse agonist effects of L-655,708 at the alpha5 subtype are not associated with a proconvulsant liability. In the Morris water maze, L-655,708 enhanced performance not only during acquisition but also in a probe trial, demonstrating that this compound has cognition enhancing effects. These data further support the potential of alpha5-containing GABA(A) receptors as a target for novel cognition enhancing drugs.




Related Products
Coluracetam
$2300/KG
NSI-189
$2300/KG
PRL-8-53
$2450/KG
Nootropics
Nancy skype: nancy_nan4
Name
CAS NO.
QUALITTY STANDARD
NSI-189 free base(hhdpharm-001)
1270138-40-3
In-hourse; 99.5% HPLC
NSI-189 phosphate(hhdpharm-002)
1270138-41-4
In-hourse; 98% HPLC
Alpha GPC (hhdpharm-003)
28319-77-9
In-hourse; 99.5% HPLC
CDP Citicoline (hhdpharm-004)
987-78-0
In-hourse; 99.5% HPLC
Citicoline Sodium
(hhdpharm-005)
33818-15-4
In-hourse; 99% HPLC
Noopept (hhdpharm-006)
157115-85-0
In-hourse; 99% HPLC
Sulbutiamine (hhdpharm-007)
3286-46-2
In-hourse; 99% HPLC
Sunifiram (hhdpharm-008)
314728-85-3
In-hourse; 99% HPLC
Unifiram (hhdpharm-009)
272786-64-8
In-hourse; 99% HPLC
PRL-8-53(hhdpharm-010)
51352-87-5
In-hourse; 99% HPLC
IDRA-21 (hhdpharm-011)
22503-72-6
In-hourse; 99% HPLC
ISRIB (hhdpharm-012)
1597403-47-8
In-hourse; 99% HPLC
Emoxypine (hhdpharm-013)
2364-75-2
In-hourse; 99% HPLC
Mexidol (hhdpharm-014)
127464-43-1
In-hourse; 99% HPLC
Vinpocetine (hhdpharm-012)
42971-09-5
In-hourse; 99% HPLC
Vincamine(hhdpharm-013)
1617-90-9
In-hourse; 99% HPLC
Galanthamine(hhdpharm-014)
357-70-0
In-hourse; 99% HPLC
Galantamine Hydrobromide(hhdpharm-015)
1953/4/4
In-hourse; 99% HPLC
Huperzine A 1% 99% (hhdpharm-016)
102518-79-6
In-hourse; 99% HPLC
Memantine (hhdpharm-017)
19982-08-2
In-hourse; 99% HPLC
Memantine hydrochloride (hhdpharm-018)
41100-52-1
In-hourse; 99% HPLC
J147 (hhdpharm-019)
1146963-51-0
In-hourse; 99% HPLC
GTS-21 (hhdpharm-020)
156223-05-1
In-hourse; 99% HPLC
S-18986 (hhdpharm-021)
175340-20-2
In-hourse; 99% HPLC
Picamilon (hhdpharm-022)
62936-56-5
In-hourse; 99% HPLC
Melatonin (hhdpharm-023)
73-31-4
In-hourse; 99% HPLC
Idebenone (CV-2619) (hhdpharm-024)
58186-27-9
In-hourse; 99% HPLC
9-methyl-B-carboline (hhdpharm-025)
2521-07-5
In-hourse; 99% HPLC
Certificate
Ship & Package
Company Introduction
Wuhan Hengheda Pharm Co., Ltd. is a hi-tech enterprise located in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. Hengheda Pharm has complete administration management and a good work team, which makes us grow fast in chemicals and pharmaceutical industry.Hengheda Pharm has a novel R&D center with advanced ventilation equipment and modern experiment equipment. We offer friendly working environment and have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of these make us provide good quality products with high rating.Hengheda Pharm follows the principle of "quality first, customer above and credit fundamentality", wishing to offer the best products to our customers.
FAQ
Customer Review