High quality API Pirfenidone powder CAS 53179-13-8

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Quantity(Grams) 1 - 1000 >1000
Est. Time(days) 7 Negotiable
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Overview
Quick Details
CAS No.:
53179-13-8
Other Names:
N/A
MF:
C12H11NO
EINECS No.:
621-260-7
Place of Origin:
Hubei, China
Type:
Cardiovascular Agents, Endocrine System Agents, Immune Function Agents, Vitamins, Amino Acids and Coenzymes, Central Nervous System Agents
Grade Standard:
Tech Grade
Usage:
Animal Pharmaceuticals
Brand Name:
HHD
Model Number:
HHD-PR
Purity:
98%
Product Name:
Pirfenidone
Appearance:
White Powder
CAS:
53179-13-8
Molecular Formula:
C12H11NO
Molecular Weight:
185.22
Grade:
Phamaceutical Grade
Specification:
98% HPLC
Storage:
Cool Dried Storage
Package:
Aluminum Foil Bag
Shelf life:
2 Years
Packaging & Delivery
Port
SH PORT
Lead Time :
Quantity(Grams) 1 - 1000 >1000
Est. Time(days) 7 To be negotiated
Product Description
Product Name:
Pirfenidone
CAS:
53179-13-8
Molecular Formula:
C12H11NO
Molecular Weight:
185.22
EINECS:
621-260-7
Function
 In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement,reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity. 
Application

Pirfenidone

is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.

In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013.

 

  In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

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Company Introduction
Wuhan Hengheda Pharm Co., Ltd. is a hi-tech enterprise located in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. Hengheda Pharm has complete administration management and a good work team, which makes us grow fast in chemicals and pharmaceutical industry.Hengheda Pharm has a novel R&D center with advanced ventilation equipment and modern experiment equipment. We offer friendly working environment and have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of these make us provide good quality products with high rating.Hengheda Pharm follows the principle of "quality first, customer above and credit fundamentality", wishing to offer the best products to our customers.
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