High quality 99% Urolithin A CAS1143-70-0 with best price

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  • 2 - 9 Grams
    $150.00
  • >=10 Grams
    $95.00
Lead Time:
Quantity(Grams) 1 - 100 >100
Est. Time(days) 7 Negotiable
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Overview
Quick Details
Type:
Herbal Extract
Variety:
Pomegranate extract
Form:
Powder
Part:
Seed
Extraction Type:
Liquid-Solid Extraction
Packaging:
Bottle, Plastic Container, Vacuum Packed
Place of Origin:
Hubei, China
Grade:
pharm grade
Brand Name:
HHD
Model Number:
HHD-NSS
Product name:
Urolithin A
CAS:
1143-70-0
Specification:
99%
Molecular formula:
C13H8O4
Molecular Weight:
228.203
Application:
Pharmaceutical Raw Materials
Storage:
cool and dried place
Shelf life:
2 Years Proper Storage
Packaging & Delivery
Lead Time :
Quantity(Grams) 1 - 100 >100
Est. Time(days) 7 To be negotiated
Product Description
Application

Urolithins are microflora human metabolites of dietary ellagic acid derivatives[1] such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate,[2] strawberries, red raspberries, walnuts or oak-aged red wine.[3]

During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans.[2][4] Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.[5]

Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.[6]

Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.[7]

Urolithin M7 has also been synthetized from 2-hydroxy-4-methoxybenzaldehyde using the inverse electron-demand Diels–Alder reaction.[8]


In laboratory studies, urolithin A was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[15] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).[15]

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Company Introduction
Wuhan Hengheda Pharm Co., Ltd. is a hi-tech enterprise located in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. Hengheda Pharm has complete administration management and a good work team, which makes us grow fast in chemicals and pharmaceutical industry.Hengheda Pharm has a novel R&D center with advanced ventilation equipment and modern experiment equipment. We offer friendly working environment and have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of these make us provide good quality products with high rating.Hengheda Pharm follows the principle of "quality first, customer above and credit fundamentality", wishing to offer the best products to our customers.
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