Factory supply Nootrpics Sunifiram DM-235 CAS 314728-85-3

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Overview
Quick Details
CAS No.:
314728-85-3
Other Names:
Sunifiram
MF:
C19H23N3O3
EINECS No.:
/
Place of Origin:
Wuhan,China(Mainland)
Type:
Vitamins, Amino Acids and Coenzymes, Central Nervous System Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
hengheda
Model Number:
hhd-Sunifiram
Purity:
99%min, 99%min
Product name:
Sunifiram
Appearance:
white Powder
Function:
Nootropics
Grade:
Medicine grade and food grade
COA:
Available
Stock:
Available
Certification:
ISO 9001, IQ Net, SGS
Shelf Life:
2 Years
Density:
1.291g/cm3
Application:
Pharmaceutical Raw Intermediates
Supply Ability
Supply Ability:
10 Kilogram/Kilograms per Month
Packaging & Delivery
Packaging Details
5 grams/Al-foil bag
10 grams/Al-foil bag
100 grams/Al-foil bag
1kg/Al-foil bag
or upon customers' request.
Port
Main port in China

Factory offer Nootrpics Sunifiram DM-235 CAS 314728-85-3

 

Product Information                                                                                                                                     

 

Sunifiram 

Cas 314728-85-3

Synonym 1-benzoyl-4-propanoylpiperazine

Formula: C14H18N2O2

Molecular Weight  246.304

Melting point 94.5°C-95.5°C

Appearance Off-white to white crystalline powder 

Asssy 99%+

 

 

 Sunifiram is a piperazine derived ampakine drug which acts as a positive allosteric 

 modulator of AMPA receptors, and has nootropic effects in animal studies with significantly

 higher potency than piracetam. A number of related compounds are known, the best known being unifiram

 

This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.

 

  Function

1.Sunifiram activates AMPA-mediated neurotransmission. 

2.Enhancing LTP in a bell-shaped dose–response relationship.  

3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.

 

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